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Low-coverage whole genome sequencing
The most cost-effective technology for genome-wide discovery

Gencove has developed a new low-coverage Whole Genome Sequencing (WGS) process to replace commonly used SNP Arrays. We sequence a random 10% to 20% of the genome in contrast to a SNP array, where about 0.02% of the genome is covered. Using a method called imputation, we can compare the sequenced bits to reference genomes and fill in many of the blanks.

Participant recruitment and engagement
More options to connect with DNA data

Recruit users with existing DNA data

Our platform gives you easy access to recruit the 8+million people that already have DNA data. When they access your study with our API you get their genotype file and an imputed .vcf file.

Full end-to-end sample collection logistics

Use our API to let users order their saliva collection kits directly from us or we can send them to you to manage the process. We offer full shipping logistics and sample processing using our low-coverage sequencing technology.

Phenotypic data capture and participant engagement

Our API can easily integrate with a website or app that you use to recruit, engage or phenotype participants. Our team can also work with you to create the perfect tool for your study.

See examples here 

Participant incentives

Your participants can get all the benefits of a Gencove account including Ancestry, Microbiome and Sleep analysis, as well as direct access to all the third party applications that connect with Gencove.

Learn more about the user experience  

Track & Manage
Manage the process in real time

The Gencove platform allows you to track every step of your research project and your participant activity. You also get immediate access to your resulting data in multiple formats. 

Frequently asked questions

Don’t find your question? Email us at

What is the advantage of using an API instead of requesting a file upload?

User uploads can come from many different companies and in many different formats, and user errors mean that files are sometimes corrupted. User uploads also are not possible on mobile devices. We handle all of these issues, and standardize the genomic data using imputation. Once a user has their data on Gencove, it’s available to you whether the user reaches your site on desktop or mobile.

What data are available through the API?

The data you can request from a user include the original genotype/sequencing data (e.g. a sequencing BAM file or an ancestryDNA text file), an imputed VCF, an ancestry summary for the individual and (if applicable) a microbiome summary.

Can you help me build an app or website for phenotyping?

Yes, please contact us at to discuss your project.

What is genotype imputation?

Genotype imputation is a method for using measured genetic variants to fill in the “missing” ones that have not been measured. It works because we know from thousands of sequenced genomes that there are set of genetic variants that are all found together, and so if you measure one of them you can guess with high probability to remainder. Learn more on Wikipedia.

What reference panel do you use for imputation?

We currently use the 1000 Genomes Phase 3 reference panel. We are experimenting with the Haplotype Reference Consortium data, if you have specific reference panel needs, please contact us at

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